COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity of SARS-CoV and SARS-CoV-2 and a shared viral...

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Bibliographic Details
Main Authors: Marko Popovic, Jennifer H. Martin, Richard J. Head
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Viral diffusion
Pharmacology
Affinity constant
Thermodynamics
Human disease
SARS-CoV2
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023043827

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http://www.sciencedirect.com/science/article/pii/S2405844023043827

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