Small extracellular vesicles from Ptpn1-deficient macrophages alleviate intestinal inflammation by reprogramming macrophage polarization via lactadherin enrichment

Small extracellular vesicles from Ptpn1-deficient macrophages alleviate intestinal inflammation by reprogramming macrophage polarization via lactadherin enrichment

Tyrosine-protein phosphatase non-receptor type 1 (Ptpn1) is known to be involved in macrophage polarization. However, whether and how Ptpn1 regulates macrophage phenotype to affect intestinal epithelial barrier function remains largely unexplored. Herein, we investigated the impact of Ptpn1 and macr...

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Bibliographic Details
Main Authors: Dandan Han, Dongdong Lu, Shimeng Huang, Jiaman Pang, Yujun Wu, Jie Hu, Xiangyu Zhang, Yu Pi, Guolong Zhang, Junjun Wang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Redox Biology
Subjects:
Intestinal inflammation
Macrophage reprogramming
Ptpn1
Small extracellular vesicles
Lactadherin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003305

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http://www.sciencedirect.com/science/article/pii/S2213231722003305

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