Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin

Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin

Clostridium perfringens alpha-toxin is a key mediator of gas gangrene, which is a life-threatening infection that manifests as fever, pain, edema, myonecrosis, and gas production. Alpha-toxin possesses phospholipase C and sphingomyelinase activities. The toxin is composed of an N-terminal domain (1–...

Full description

Bibliographic Details
Main Authors: Masataka Oda, Yutaka Terao, Jun Sakurai, Masahiro Nagahama
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Toxins
Subjects:
Clostridium perfringens
alpha-toxin
C-domain
central loop domain
phospholipid
ganglioside GM1a
TrkA
endocytosis
vaccine
Online Access:http://www.mdpi.com/2072-6651/7/12/4880

Internet

http://www.mdpi.com/2072-6651/7/12/4880

Similar Items