Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities
Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism phy...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222000836 |
| _version_ | 1797802208458178560 |
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| author | Guo Zhao Junfeng Zhen Xinyuan Liu Jinshuai Guo Duanduan Li Jianping Xie Longxiang Xie |
| author_facet | Guo Zhao Junfeng Zhen Xinyuan Liu Jinshuai Guo Duanduan Li Jianping Xie Longxiang Xie |
| author_sort | Guo Zhao |
| collection | DOAJ |
| description | Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes, such as tumorigenesis and metabolic diseases. To provide an understanding of the molecular mechanism and functions of Ksuc in different organisms, we reviewed the current literature about Ksuc, mainly summarizing the research advances in eukaryotes and prokaryotes based on both traditional study methods and site prediction tools. We also discussed inhibitors or activators associated with Ksuc that may contribute to proteomic studies and could be useful in future clinical practice. A deeper understanding of Ksuc may shed new light on life science at the protein level and could lead to novel therapeutic strategies for various diseases. |
| first_indexed | 2024-03-13T05:02:44Z |
| format | Article |
| id | doaj.art-ecfc8c2ef9994f5a920eebf5a3014d74 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-13T05:02:44Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-ecfc8c2ef9994f5a920eebf5a3014d742023-06-17T05:18:57ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-07-0110412421262Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunitiesGuo Zhao0Junfeng Zhen1Xinyuan Liu2Jinshuai Guo3Duanduan Li4Jianping Xie5Longxiang Xie6Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, ChinaInstitute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaInstitute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaInstitute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, China; Corresponding author.Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Corresponding author.Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes, such as tumorigenesis and metabolic diseases. To provide an understanding of the molecular mechanism and functions of Ksuc in different organisms, we reviewed the current literature about Ksuc, mainly summarizing the research advances in eukaryotes and prokaryotes based on both traditional study methods and site prediction tools. We also discussed inhibitors or activators associated with Ksuc that may contribute to proteomic studies and could be useful in future clinical practice. A deeper understanding of Ksuc may shed new light on life science at the protein level and could lead to novel therapeutic strategies for various diseases.http://www.sciencedirect.com/science/article/pii/S2352304222000836DiseaseEukaryotesLysine succinylationPhysiologyProkaryotesProtein post-translational modification |
| spellingShingle | Guo Zhao Junfeng Zhen Xinyuan Liu Jinshuai Guo Duanduan Li Jianping Xie Longxiang Xie Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities Genes and Diseases Disease Eukaryotes Lysine succinylation Physiology Prokaryotes Protein post-translational modification |
| title | Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities |
| title_full | Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities |
| title_fullStr | Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities |
| title_full_unstemmed | Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities |
| title_short | Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities |
| title_sort | protein post translational modification by lysine succinylation biochemistry biological implications and therapeutic opportunities |
| topic | Disease Eukaryotes Lysine succinylation Physiology Prokaryotes Protein post-translational modification |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222000836 |
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