Knockdown <i>SENP1</i> Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression

Knockdown <i>SENP1</i> Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression

The angiogenic potential of mesenchymal stem cells (MSCs) is critical for adult vascular regeneration and repair, which is regulated by various growth factors and cytokines. In the current study, we report that knockdown SUMO-specific peptidase 1 (SENP1) stimulated the SUMOylation of MRTF-A and prev...

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Bibliographic Details
Main Authors: Rui Zhang, Qingxi Liu, Cuicui Lyu, Xing Gao, Wenjian Ma
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
human mesenchymal stem cells (hMSCs)
SENP1
CXCR4
CCN1
SUMOylation
MRTF-A
Online Access:https://www.mdpi.com/2227-9059/11/3/914

Internet

https://www.mdpi.com/2227-9059/11/3/914

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