Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes.

Recent studies have been successful at utilizing ectopic expression of transcription factors to generate induced cardiomyocytes (iCMs) from fibroblasts, albeit at a low frequency in vitro. This work investigates the influence of small molecules that have been previously reported to improve different...

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Bibliographic Details
Main Authors: Jamie L Ifkovits, Russell C Addis, Jonathan A Epstein, John D Gearhart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089678&type=printable