A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma

The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 inhibition blocks GBM-driven tumor growth. STAT3...

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Bibliographic Details
Main Authors: Sujoy Bhattacharya, Lawrence M. Pfeffer, Edward Chaum
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Autophagy Reports
Subjects:
Online Access:http://dx.doi.org/10.1080/27694127.2022.2117340