A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma
The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 inhibition blocks GBM-driven tumor growth. STAT3...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/27694127.2022.2117340 |
| _version_ | 1827818572677644288 |
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| author | Sujoy Bhattacharya Lawrence M. Pfeffer Edward Chaum |
| author_facet | Sujoy Bhattacharya Lawrence M. Pfeffer Edward Chaum |
| author_sort | Sujoy Bhattacharya |
| collection | DOAJ |
| description | The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 inhibition blocks GBM-driven tumor growth. STAT3 regulates macroautophagy/autophagy, a central player in GBM pathobiology. Although autophagy suppression has been implicated in the pathophysiology of GBM, it is unknown if modulation of autophagy can reduce GBM tumorigenesis. Based on observations from our recent study, the answer appears to be yes, and we propose a therapeutic strategy for dual inhibition of STAT3 and MTOR, or STAT3 and ULK1 to target GBM tumorigenesis and chemoresistance. |
| first_indexed | 2024-03-12T00:55:43Z |
| format | Article |
| id | doaj.art-ed062b443e3543afaa92eaf263ca3e11 |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:55:43Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-ed062b443e3543afaa92eaf263ca3e112023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272022-12-011138538810.1080/27694127.2022.21173402117340A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in GlioblastomaSujoy Bhattacharya0Lawrence M. Pfeffer1Edward Chaum2Vanderbilt University Medical CenterThe Center for Cancer Research, College of Medicine, University of Tennessee Health Science CenterVanderbilt University Medical CenterThe aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 inhibition blocks GBM-driven tumor growth. STAT3 regulates macroautophagy/autophagy, a central player in GBM pathobiology. Although autophagy suppression has been implicated in the pathophysiology of GBM, it is unknown if modulation of autophagy can reduce GBM tumorigenesis. Based on observations from our recent study, the answer appears to be yes, and we propose a therapeutic strategy for dual inhibition of STAT3 and MTOR, or STAT3 and ULK1 to target GBM tumorigenesis and chemoresistance.http://dx.doi.org/10.1080/27694127.2022.2117340ampkαapoptosiscaspase 3cathepsin dlc3-i/lc3-iimtorc1rad001 (everolimus)ulk1 |
| spellingShingle | Sujoy Bhattacharya Lawrence M. Pfeffer Edward Chaum A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma Autophagy Reports ampkα apoptosis caspase 3 cathepsin d lc3-i/lc3-ii mtorc1 rad001 (everolimus) ulk1 |
| title | A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma |
| title_full | A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma |
| title_fullStr | A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma |
| title_full_unstemmed | A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma |
| title_short | A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma |
| title_sort | novel combination therapy approach targeting stat3 and autophagy in glioblastoma |
| topic | ampkα apoptosis caspase 3 cathepsin d lc3-i/lc3-ii mtorc1 rad001 (everolimus) ulk1 |
| url | http://dx.doi.org/10.1080/27694127.2022.2117340 |
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