A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma

A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma

Background: We have recently introduced an intelligent RNA expression device (iRed), comprising the minimum essential components needed to transcribe short hairpin RNA (shRNA) in cells. Use of iRed efficiently produced shRNA molecules after transfection into cells and alleviated the innate immune st...

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Bibliographic Details
Main Authors: Hidenori Ando, Noriko Saito-Tarashima, Amr S. Abu Lila, Nozomi Kinjo, Taro Shimizu, Yu Ishima, Noriaki Minakawa, Tatsuhiro Ishida
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
cationic liposomes
innate immunity
intelligent RNA expression device (iRed)
RNA interference
shRNA
Online Access:https://www.mdpi.com/1420-3049/25/7/1725

Internet

https://www.mdpi.com/1420-3049/25/7/1725

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