LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II–mediated signaling

LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II–mediated signaling

Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recognizes numerous ligands, including apolipoprotein E–ri...

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Bibliographic Details
Main Authors: Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.164751

Internet

https://doi.org/10.1172/jci.insight.164751

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