Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation

Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation

Abstract Background Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantation (FMT) from healthy donors are at an increased risk of developing bacteremia. This study investigates the efficacy of a mixture of seven short-chain fatty...

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Bibliographic Details
Main Authors: Hailan Zhao, Youlian Zhou, Jing Xu, Yong Zhang, Hong Wang, Chong Zhao, Hongli Huang, Jing Yang, Chen Huang, Yingfei Li, Lisheng Wang, Yuqiang Nie
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Translational Medicine
Subjects:
Short-chain fatty acids
Bacterial mixture
Macrophage polarization
Colitis
Online Access:https://doi.org/10.1186/s12967-024-05122-w

Internet

https://doi.org/10.1186/s12967-024-05122-w

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