The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity. Originally identified for their role in desensitization, internalization and recycling of G protein-coup...

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Bibliographic Details
Main Authors: Suleiman Al-Sabah, Lobna Adi, Moritz Bünemann, Cornelius Krasel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
G protein-coupled receptor
arrestin
fluorescence resonance energy transfer
bioluminescence resonance energy transfer
glucagon-like peptide-1
glucose-dependent insulinotropic polypeptide
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01271/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01271/full

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