Enhanced immunogenicity elicited by a novel DNA vaccine encoding the SARS-CoV-2 S1 protein fused to the optimized flagellin of Salmonella typhimurium in mice

Enhanced immunogenicity elicited by a novel DNA vaccine encoding the SARS-CoV-2 S1 protein fused to the optimized flagellin of Salmonella typhimurium in mice

ABSTRACT The development of safe and efficient vaccines against coronavirus disease 2019 (COVID-19) is necessary for global public health. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major target for the COVID-19 vaccines. Among the available vaccine types,...

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Bibliographic Details
Main Authors: Li Song, Qiaoju Wang, Yaya Wen, Ruimeng Tan, Yaodan Cui, Dan Xiong, Xinan Jiao, Zhiming Pan
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
S1
antibiotic-resistance gene-free vector
DNA vaccine
optimized flagellin adjuvant
immunogenicity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02549-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02549-23

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