Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones

Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones

Functionally substituted sulfones with stereogenic centers are valuable reagents in organic synthesis and key motifs in some bioactive compounds. The asymmetric Michael addition of β-ketosulfones to conjugated nitroalkenes in the presence of Ni(II) complexes with various chiral vicinal diamines was...

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Bibliographic Details
Main Authors: Alexander N. Reznikov, Anastasiya E. Sibiryakova, Marat R. Baimuratov, Eugene V. Golovin, Victor B. Rybakov, Yuri N. Klimochkin
Format: Article
Language:English
Published: Beilstein-Institut 2019-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
asymmetric catalysis
chiral diamine ligands
ketosulfones
Michael addition
nickel complexes
nitroalkenes
Online Access:https://doi.org/10.3762/bjoc.15.127

Internet

https://doi.org/10.3762/bjoc.15.127

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