Pyrazole and Triazole Derivatives as <i>Mycobacterium tuberculosis</i> UDP-Galactopyranose Inhibitors

Pyrazole and Triazole Derivatives as <i>Mycobacterium tuberculosis</i> UDP-Galactopyranose Inhibitors

UDP-galactopyranose mutase (UGM) is an essential enzyme involved in the bacterial cell wall synthesis, and is not present in mammalian cells. Thus, UGM from <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) represents a novel and attractive drug target for developing antitubercu...

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Bibliographic Details
Main Authors: Dalia M. Ahmed, Jeffrey M. Chen, David A. R. Sanders
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
pyrazoles
triazoles
UDP-galactopyranose mutase
inhibitors
antituberculosis
enzyme kinetics
Online Access:https://www.mdpi.com/1424-8247/15/2/197

Internet

https://www.mdpi.com/1424-8247/15/2/197

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