A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

Objective: GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification, i.e., O-linked glycosylation of secreted protein...

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Bibliographic Details
Main Authors: Cristy R.C. Verzijl, Federico Oldoni, Natalia Loaiza, Justina C. Wolters, Antoine Rimbert, E. Tian, Weiming Yang, Dicky Struik, Marieke Smit, Niels J. Kloosterhuis, Amy J. Fernandez, Nadine L. Samara, Kelly G. Ten Hagen, Kruti Dalal, Aliona Chernish, Peggy McCluggage, Lawrence A. Tabak, Johan W. Jonker, Jan Albert Kuivenhoven
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Metabolism
Subjects:
Glycosylation
Genetic disorder
Energy metabolism
Adipose tissue
Insulin signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000412

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http://www.sciencedirect.com/science/article/pii/S2212877822000412

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