Avelumab as neoadjuvant therapy in patients with urothelial non-metastatic muscle invasive bladder cancer: a multicenter, randomized, non-comparative, phase II study (Oncodistinct 004 - AURA trial)

Avelumab as neoadjuvant therapy in patients with urothelial non-metastatic muscle invasive bladder cancer: a multicenter, randomized, non-comparative, phase II study (Oncodistinct 004 - AURA trial)

Abstract Introduction Cisplatin-based neoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for patients with non-metastatic muscle invasive bladder cancer (MIBC). Unfortunately, many patients are not candidates to receive cisplatin due to renal impairment. Additionally, no pr...

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Bibliographic Details
Main Authors: Nieves Martinez Chanza, Louisa Soukane, Philippe Barthelemy, Aurélien Carnot, Thierry Gil, Vinciane Casert, Vincent Vanhaudenarde, Brieuc Sautois, Lionel Staudacher, Jan Van den Brande, Stephane Culine, Emmanuel Seront, Marco Gizzi, Simone Albisinni, Thibault Tricard, Jean Christophe Fantoni, Marianne Paesmans, Rafael Caparica, Thierry Roumeguere, Ahmad Awada
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Cancer
Subjects:
Avelumab
Bladder cancer
Checkpoint inhibitor
Immunotherapy
Neoadjuvant
PD-1 blockade
Online Access:https://doi.org/10.1186/s12885-021-08990-3

Internet

https://doi.org/10.1186/s12885-021-08990-3

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