Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

Current hypotheses and theories regarding the pathogenesis of Alzheimer’s disease (AD) heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well-validated metrics for systemic IR, the absence of biomarkers for brain-specific IR represents a translational gap that has hin...

Full description

Bibliographic Details
Main Authors: Roger J. Mullins, Thomas C. Diehl, Chee W. Chia, Dimitrios Kapogiannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
insulin resistance
magnetic resonance spectroscopy
exosomes
IRS-1
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00118/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00118/full

Similar Items