CTG trinucleotide repeat "big jumps": large expansions, small mice.
Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC1847694?pdf=render |