Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA<sub>4</sub>H). Compounds capable of limiting the formation of LTB4,...

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Bibliographic Details
Main Authors: Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
leukotriene A4 hydrolase
leukotriene B4
anti-cancer and anti-inflammatory agents
pharmacophore modeling
moelcular docking
Online Access:https://www.mdpi.com/1420-3049/25/12/2871

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https://www.mdpi.com/1420-3049/25/12/2871

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