Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-<i>γ</i>-Cyclodextrin

Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-<i>γ</i>-Cyclodextrin

Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility; however, a significant result has yet to be achiev...

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Bibliographic Details
Main Authors: Yili Ding, Wutong Cui, Zhiyuan Zhang, Yanzhi Ma, Charles Ding, Yikai Lin, Zhe Xu
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
griseofulvin
HP-<i>γ</i>-cyclodextrin
inclusion complex
preparation
water solubility
in vitro and in vivo PK study
Online Access:https://www.mdpi.com/1420-3049/28/21/7360

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https://www.mdpi.com/1420-3049/28/21/7360

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