Modified N-acyl-L-homoserine lactone compounds abrogate Las-dependent quorum-sensing response in human pathogen Pseudomonas aeruginosa

Modified N-acyl-L-homoserine lactone compounds abrogate Las-dependent quorum-sensing response in human pathogen Pseudomonas aeruginosa

Quorum sensing (QS) is a mode of cell–cell communication that bacteria use to sense population density and orchestrate collective behaviors. The common opportunistic human pathogen Pseudomonas aeruginosa employs QS to regulate a large set of genes involved in virulence and host–pathogen interactions...

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Bibliographic Details
Main Authors: Flavio Ballante, Maria V. Turkina, Maria Ntzouni, Karl-Eric Magnusson, Elena Vikström
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Pseudomonas aeruginosa
quorum sensing
antivirulence strategy
small-molecule probes
N-acyl-L-homoserine lactone
LasR
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1264773/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1264773/full

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