Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice

Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice

Background: Chronic kidney disease (CKD) is a public health problem of which the prevalence is increasing worldwide. Several studies have reported that ambient particulate matter (PM) causes kidney injury, which may be related to the risk of CKD. However, the underlying molecular mechanisms have not...

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Bibliographic Details
Main Authors: Jinjin Jiang, Shibin Ding, Guofu Zhang, Yaqi Dong
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Particulate matter
High-fat diet
Inflammation
Renal fibrosis
NLRP3 inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322004110

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http://www.sciencedirect.com/science/article/pii/S0147651322004110

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