Empagliflozin and Dapagliflozin Increase Na<sup>+</sup> and Inward Rectifier K<sup>+</sup> Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Empagliflozin and Dapagliflozin Increase Na<sup>+</sup> and Inward Rectifier K<sup>+</sup> Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients. Sodium and inward rectifier K<sup>+</sup> currents (I<sub>Na</sub> and I<sub>K1</sub>), carrie...

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Bibliographic Details
Main Authors: María Dago, Teresa Crespo-García, Anabel Cámara-Checa, Josu Rapún, Marcos Rubio-Alarcón, María Marín, Juan Tamargo, Ricardo Caballero, Eva Delpón
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
empagliflozin
dapagliflozin
sodium current
inward rectifier current
human cardiomyocytes
Online Access:https://www.mdpi.com/2073-4409/11/23/3707

Internet

https://www.mdpi.com/2073-4409/11/23/3707

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