The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics

The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics

CYP2D6 and CYP2C19 enzymes are essential in the metabolism of antidepressants and antipsychotics. Genetic variation in these genes may increase risk of adverse drug reactions. Antidepressants and antipsychotics have previously been associated with risk of diabetes. We examined whether individual gen...

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Bibliographic Details
Main Authors: Isabelle Austin-Zimmerman, Marta Wronska, Baihan Wang, Haritz Irizar, Johan H. Thygesen, Anjali Bhat, Spiros Denaxas, Ghazaleh Fatemifar, Chris Finan, Jasmine Harju-Seppänen, Olga Giannakopoulou, Karoline Kuchenbaecker, Eirini Zartaloudi, Andrew McQuillin, Elvira Bramon
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Genes
Subjects:
CYP2C19
CYP2D6
pharmacogenetics
diabetes
personalized medicine
HbA1c
Online Access:https://www.mdpi.com/2073-4425/12/11/1758

Internet

https://www.mdpi.com/2073-4425/12/11/1758

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