Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation of a drugs biodistribution within the tissue is impossible. In the st...

Full description

Bibliographic Details
Main Authors: Andreas Dannhorn, Emine Kazanc, Gregory Hamm, John G. Swales, Nicole Strittmatter, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Metabolites
Subjects:
DESI
MALDI
mass spectrometry imaging
DMPK
drug absorption
tissue imaging
Online Access:https://www.mdpi.com/2218-1989/12/3/261

Internet

https://www.mdpi.com/2218-1989/12/3/261

Similar Items