Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.

Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.

Giardiasis and other protozoan infections are major worldwide causes of morbidity and mortality, yet development of new antimicrobial agents with improved efficacy and ability to override increasingly common drug resistance remains a major challenge. Antimicrobial drug development typically proceeds...

Full description

Bibliographic Details
Main Authors: Tineke Lauwaet, Yukiko Miyamoto, Sozaburo Ihara, Christine Le, Jarosław Kalisiak, Keith A Korthals, Majid Ghassemian, Diane K Smith, K Barry Sharpless, Valery V Fokin, Lars Eckmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008224

Internet

https://doi.org/10.1371/journal.pntd.0008224

Similar Items