Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation

Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation

Background: Drug-induced liver injury is one of the main reasons of withdrawals of drugs in postmarketing stages. However, an experimental model(s) which can accurately recapitulates liver functions and reflects the level of drug hepatotoxicity is lack. In this study, we assessed drug hepatotoxicity...

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Bibliographic Details
Main Authors: Jiecheng Xu, Daogang Pan, Wei Liao, Zhidong Jia, Mingxin Pan, Jun Weng, Xu Han, Shao Li, Yang Li, Kangyan Liang, Shuqin Zhou, Qing Peng, Yi Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
3D culture
hydrogel
hepatic plate
polarity
drug-induced liver injury (DILI)
statins
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.826093/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2022.826093/full

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