Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic cycle involves the formation of a short-lived covalent complex with the 3′ end of DNA (TOP1 cleavage complex, TOP1cc), which can be stabiliz...

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Main Authors: Nadezhda S. Dyrkheeva, Anastasia A. Malakhova, Aleksandra L. Zakharenko, Larisa S. Okorokova, Dmitriy N. Shtokalo, Sophia V. Pavlova, Sergey P. Medvedev, Suren M. Zakian, Anna A. Nushtaeva, Alexey E. Tupikin, Marsel R. Kabilov, Svetlana N. Khodyreva, Olga A. Luzina, Nariman F. Salakhutdinov, Olga I. Lavrik
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
poly(ADP-ribose) polymerase 1
HEK293A
transcriptome
PARP1 knockout
topoisomerase 1
tyrosyl-DNA phosphodiesterase 1
Online Access:https://www.mdpi.com/1422-0067/24/6/5148

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https://www.mdpi.com/1422-0067/24/6/5148

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