Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

Abstract Cardiac function requires appropriate proteins in each chamber. Atria requires slow myosin to act as reservoirs, while ventricles demand fast myosin for swift pumping. Myosins are thus under chamber-biased cis-regulation, with myosin gene expression imbalances leading to congenital heart dy...

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Bibliographic Details
Main Authors: Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, João E. Carvalho, Allysson Coelho Sampaio, Frank E. Stockdale, Gang Feng Wang, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia Rosenthal, Patricia Regina Jusuf, Hieu T. Nim, Paulo de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, Izabella Luisa Tambones, Ana Carolina Migliorini Figueira, Michael Schubert, Mirana Ramialison, José Xavier-Neto
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05972-6

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https://doi.org/10.1038/s42003-024-05972-6

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