Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Abstract Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-domain III containing 5 (FNDC5), mediates the pleiotropic effects of exer...

Full description

Bibliographic Details
Main Authors: Cailin Wang, Xiufeng Wang, Shangqi Sun, Yanmin Chang, Piaopiao Lian, Hongxiu Guo, Siyi Zheng, Rong Ma, Gang Li
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Immunity & Ageing
Subjects:
Tau
Irisin
Microglial senescence
TFAM
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s12979-024-00437-0

Internet

https://doi.org/10.1186/s12979-024-00437-0

Similar Items