MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery smooth muscle cells (PASMCs) and lungs of pulmonary hypertension (PH) patients and rodents with experimental PH. We found tha...

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Bibliographic Details
Main Authors: Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Dustin R. Fraidenburg, Balaji Ganesh, Mark Maienschein-Cline, Karl Obrietan, J. Usha Raj
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
pulmonary hypertension
pulmonary vascular remodeling
pulmonary artery smooth muscle cells
microRNAs
engineered extracellular vesicles
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001603

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http://www.sciencedirect.com/science/article/pii/S2162253122001603

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