Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function

Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function

Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein podoplanin (PDPN) on FRCs, inhibiting actomyosin contractility through the FRC netwo...

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Bibliographic Details
Main Authors: Shu En Lim, Megan D. Joseph, Charlotte M. de Winde, Sophie E. Acton, Sabrina Simoncelli
Format: Article
Language:English
Published: The Royal Society 2023-05-01
Series:Open Biology
Subjects:
super-resolution
DNA-PAINT
qPAINT
podoplanin
CLEC-2
CD44
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.220377

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.220377

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