Injectable Polypeptide Hydrogel Depots Containing Dual Immune Checkpoint Inhibitors and Doxorubicin for Improved Tumor Immunotherapy and Post-Surgical Tumor Treatment

Injectable Polypeptide Hydrogel Depots Containing Dual Immune Checkpoint Inhibitors and Doxorubicin for Improved Tumor Immunotherapy and Post-Surgical Tumor Treatment

In this work, we developed a strategy for local chemo-immunotherapy through simultaneous incorporation of dual immune checkpoint blockade (ICB) antibodies, anti-cytotoxic T-lymphocyte-associated protein 4 (aCTLA-4) and anti-programmed cell death protein 1 (aPD-1), and a chemotherapy drug, doxorubici...

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Bibliographic Details
Main Authors: Zhixiong Chen, Yan Rong, Junfeng Ding, Xueliang Cheng, Xuesi Chen, Chaoliang He
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
hydrogel
combination therapy
immunotherapy
polypeptide
ICB therapy
Online Access:https://www.mdpi.com/1999-4923/15/2/428

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https://www.mdpi.com/1999-4923/15/2/428

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