Multi-Omics Analysis Revealed a Significant Alteration of Critical Metabolic Pathways Due to Sorafenib-Resistance in Hep3B Cell Lines

Multi-Omics Analysis Revealed a Significant Alteration of Critical Metabolic Pathways Due to Sorafenib-Resistance in Hep3B Cell Lines

Hepatocellular carcinoma (HCC) is the second prominent cause of cancer-associated death worldwide. Usually, HCC is diagnosed in advanced stages, wherein sorafenib, a multiple target tyrosine kinase inhibitor, is used as the first line of treatment. Unfortunately, resistance to sorafenib is usually e...

Full description

Bibliographic Details
Main Authors: Kholoud Y. I. Abushawish, Sameh S. M. Soliman, Alexander D. Giddey, Hamza M. Al-Hroub, Muath Mousa, Karem H. Alzoubi, Waseem El-Huneidi, Eman Abu-Gharbieh, Hany A. Omar, Sara M. Elgendy, Yasser Bustanji, Nelson C. Soares, Mohammad H. Semreen
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
proteomics
metabolomics
parental Hep3B cells
sorafenib-resistant Hep3B cells
UHPLC-QTOF-MS
Online Access:https://www.mdpi.com/1422-0067/23/19/11975

Internet

https://www.mdpi.com/1422-0067/23/19/11975

Similar Items