Heterologous prime-boost immunisation with mRNA- and AdC68-based 2019-nCoV variant vaccines induces broad-spectrum immune responses in mice

Heterologous prime-boost immunisation with mRNA- and AdC68-based 2019-nCoV variant vaccines induces broad-spectrum immune responses in mice

The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCoV) variants has been associated with the transmission and pathogenicity of COVID-19. Therefore, exploring the optimal immunisation strategy to improve the broad-spectrum cross-protection ability of COVID-...

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Bibliographic Details
Main Authors: Xingxing Li, Jingjing Liu, Wenjuan Li, Qinhua Peng, Miao Li, Zhifang Ying, Zelun Zhang, Xinyu Liu, Xiaohong Wu, Danhua Zhao, Lihong Yang, Shouchun Cao, Yanqiu Huang, Leitai Shi, Hongshan Xu, Yunpeng Wang, Guangzhi Yue, Yue Suo, Jianhui Nie, Weijin Huang, Jia Li, Yuhua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
heterologous prime-boost
ChAdTS-S
ARCoV
intramuscular
intranasal
SARS-COV-2 variants
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142394/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142394/full

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