The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells

The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells

Abstract Cardiac development involves large‐scale rearrangements of the proteome. How the developing cardiac cells maintain the integrity of the proteome during the rapid lineage transition remains unclear. Here it is shown that proteotoxic stress visualized by the misfolded and/or aggregated protei...

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Bibliographic Details
Main Authors: Fang Liu, Zhun Liu, Weisheng Cheng, Qingquan Zhao, Xinyu Zhang, He Zhang, Miao Yu, He Xu, Yichen Gao, Qianrui Jiang, Guojun Shi, Likun Wang, Shanshan Gu, Jia Wang, Nan Cao, Zhongyan Chen
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
human pluripotent stem cells
mesendoderm specification
PERK
proteostasis
unfolded protein response
Online Access:https://doi.org/10.1002/advs.202303799

Internet

https://doi.org/10.1002/advs.202303799

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