Synthesis and Evaluation of Phenyltriazole-Deoxynojirimycin Hybrids as Potent α-Glucosidase Inhibitors

Synthesis and Evaluation of Phenyltriazole-Deoxynojirimycin Hybrids as Potent α-Glucosidase Inhibitors

1-deoxynojirimycin (DNJ) is a well-known α-glucosidase inhibitor. A series of phenyltriazole-deoxynojirimycin hybrids containing C<sub>4</sub> and C<sub>6</sub> (4 and 6 methylenes, respectively) linkers were synthesized. These novel compounds were assessed for preliminary gl...

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Bibliographic Details
Main Authors: Lin Wang, Wei Luo, Yonghong Zhao, Xinling Guo, Xiangru Bai, Leilei Guo, Nailiang Zhu
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
Subjects:
1-deoxynojirimycn
α-glucosidase
docking simulation
competitive inhibitor
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/29/21/5062

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https://www.mdpi.com/1420-3049/29/21/5062

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