Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells....
Главные авторы: | , , , , , , , , , , , , , , |
---|---|
Формат: | Статья |
Язык: | English |
Опубликовано: |
Nature Portfolio
2020-01-01
|
Серии: | Nature Communications |
Online-ссылка: | https://doi.org/10.1038/s41467-019-14184-0 |