R848 Adjuvant Laden With Self-Assembled Nanoparticle-Based mRNA Vaccine Elicits Protective Immunity Against H5N1 in Mice

R848 Adjuvant Laden With Self-Assembled Nanoparticle-Based mRNA Vaccine Elicits Protective Immunity Against H5N1 in Mice

In order to perfect the design strategy of messenger RNA (mRNA) vaccines against the H5N1 influenza virus, we investigated whether different antigen designs and the use of adjuvants could improve the immune effect of mRNA vaccines. We designed three different forms of antigen genes, including Flu [H...

Full description

Bibliographic Details
Main Authors: Xinyu Zhuang, Luer Chen, Songhui Yang, Shengnan Xia, Zhiqiang Xu, Tong Zhang, Boyu Zeng, Tong Yu, Ning Yu, Wei Wang, Huijun Lu, Mingyao Tian, Ningyi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
mRNA vaccine
ferritin
CD5 signal peptide
R848
H5N1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.836274/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.836274/full

Similar Items