Advances in Gene Therapy Techniques to Treat <i>LRRK2</i> Gene Mutation

Advances in Gene Therapy Techniques to Treat <i>LRRK2</i> Gene Mutation

Leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene mutation is an autosomal dominant mutation associated with Parkinson’s disease (PD). Among <i>LRRK2</i> gene mutations, the <i>LRRK2</i> G2019S mutation is frequently involved in PD onset. Currently, diverse gene co...

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Bibliographic Details
Main Authors: Sun-Ku Chung, Seo-Young Lee
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
<i>LRRK2</i> G2019S
zinc finger nucleases
helper-dependent adenoviral vector
CRISPR/Cas9-HDR
adenine base editor
bacterial artificial chromosome-based homologous recombination
Online Access:https://www.mdpi.com/2218-273X/12/12/1814

Internet

https://www.mdpi.com/2218-273X/12/12/1814

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