Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD<sup>+</sup>-Glycohydrolase: Evidence for Extracellular Activity

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD<sup>+</sup>-Glycohydrolase: Evidence for Extracellular Activity

ABSTRACT Group A Streptococcus (GAS) is a common human pathogen and the etiologic agent of a large number of diseases ranging from mild, self-limiting infections to invasive life-threatening conditions. Two prominent virulence factors of this bacterium are the genetically and functionally linked por...

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Bibliographic Details
Main Authors: Dóra Hancz, Elsa Westerlund, Benedicte Bastiat-Sempe, Onkar Sharma, Christine Valfridsson, Lena Meyer, John F. Love, Maghnus O’Seaghdha, Michael R. Wessels, Jenny J. Persson
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Streptococcus pyogenes
host-pathogen interactions
immune regulation
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/mBio.00756-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00756-17

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