The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of <i>Plasmodium falciparum</i> Viability after Antimalarial Treatment In Vitro

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of <i>Plasmodium falciparum</i> Viability after Antimalarial Treatment In Vitro

With artemisinin-resistant <i>Plasmodium falciparum</i> parasites emerging in Africa, the need for new antimalarial chemotypes is persistently high. The ideal pharmacodynamic parameters of a candidate drug are a rapid onset of action and a fast rate of parasite killing or clearance. To d...

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Bibliographic Details
Main Authors: Annabelle Walz, Maëlle Duffey, Ghaith Aljayyoussi, Sibylle Sax, Didier Leroy, Dominique Besson, Jeremy N. Burrows, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Marie-Anne Westwood, Christoph Siethoff, Francisco-Javier Gamo, Pascal Mäser, Sergio Wittlin
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
malaria
<i>Plasmodium falciparum</i>
parasite viability
limiting dilution
parasite reduction ratio
PRR
Online Access:https://www.mdpi.com/1424-8247/16/2/163

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https://www.mdpi.com/1424-8247/16/2/163

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