Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy

Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy

Abstract Background Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infiltrating lymphocytes. Radiation therapy (RT) can inc...

Full description

Bibliographic Details
Main Authors: Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris, Linda A. Schuler
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Breast Cancer Research
Subjects:
ER+ breast cancer
Anti-estrogen
Radiation therapy
Immunotherapy
Fulvestrant
Online Access:https://doi.org/10.1186/s13058-023-01671-y

Internet

https://doi.org/10.1186/s13058-023-01671-y

Similar Items