SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome and cytokine storm, which may result from SARS-...

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Bibliographic Details
Main Authors: Lihong Liu, Jie Du, Sidi Yang, Birong Zheng, Jian Shen, Jiacheng Huang, Liu Cao, Siyao Huang, Xue Liu, Liping Guo, Chunmei Li, Changwen Ke, Xiaofang Peng, Deyin Guo, Hong Peng
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
Subjects:
SARS-CoV-2
ORF3a
Ferroptosis
Keap1
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001532

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723001532

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