Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

The mechanisms whereby guanine nucleotide exchange factors (GEFs) coordinate their subcellular targeting to their activation of small GTPases remain poorly understood. Here we analyzed how membranes control the efficiency of human BRAG2, an ArfGEF involved in receptor endocytosis, Wnt signaling, and...

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Bibliographic Details
Main Authors: Kaheina Aizel, Valérie Biou, Jorge Navaza, Lionel V Duarte, Valérie Campanacci, Jacqueline Cherfils, Mahel Zeghouf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3769224?pdf=render

Internet

http://europepmc.org/articles/PMC3769224?pdf=render

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