Preparation and Bioevaluation of Novel <sup>99m</sup>Tc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

Preparation and Bioevaluation of Novel <sup>99m</sup>Tc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

To develop novel <sup>99m</sup>Tc-labeled single-photon emission computed tomography (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2-nitroimidazole derivative) was designed and synthesized. It was radiolabeled with technetium-99m using...

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Bibliographic Details
Main Authors: Qing Ruan, Qianqian Gan, Xuran Zhang, Si’an Fang, Junbo Zhang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
2-nitroimidazole
technetium-99m
HYNIC
tumor
hypoxia
Online Access:https://www.mdpi.com/1424-8247/14/2/158

Internet

https://www.mdpi.com/1424-8247/14/2/158

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