Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer

Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer

IntroductionMetastatic colorectal cancer (mCRC) remains a common and highly morbid disease, with a recent increase in incidence in patients younger than 50 years. There is an acute need to better understand differences in tumor biology, molecular characteristics, and other age-related differences in...

Full description

Bibliographic Details
Main Authors:	Brian D. Griffith, Jenny Lazarus, Jake McGue, Santhoshi Krishnan, Michael I. D’Angelica, Jinru Shia, Irina Dobrosotskaya, Jaiqi Shi, Jacob Edwards, Arvind Rao, Timothy L. Frankel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Immunology
Subjects:	tumor immunology colorectal cancer immunotherapy spatial relation analysis multiplex immunohistochemistry (IHC)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289402/full

Similar Items

MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment
by: Brian D. Griffith, et al.
Published: (2022-08-01)

CGAT: Cell Graph ATtention Network for Grading of Pancreatic Disease Histology Images
by: Mayank Baranwal, et al.
Published: (2021-09-01)

SPARTIN: a Bayesian method for the quantification and characterization of cell type interactions in spatial pathology data
by: Nathaniel Osher, et al.
Published: (2023-05-01)

GaWRDenMap: a quantitative framework to study the local variation in cell–cell interactions in pancreatic disease subtypes
by: Santhoshi N. Krishnan, et al.
Published: (2022-03-01)

258 Analysis of the Hepatic Microenvironment Before and After Direct-Acting Antiviral (DAA) Therapy for Viral Hepatitis C
by: Daniel Millian, et al.
Published: (2023-04-01)

Comparison of Multiplexed Immunofluorescence Imaging to Chromogenic Immunohistochemistry of Skin Biomarkers in Response to Monkeypox Virus Infection
by: Anup Sood, et al.
Published: (2020-07-01)

Primary ovarian leiomyoma
by: Shweta Raje, et al.
Published: (2020-01-01)

Cellular engagement and interaction in the tumor microenvironment predict non-response to PD-1/PD-L1 inhibitors in metastatic non-small cell lung cancer
by: Angel Qin, et al.
Published: (2022-05-01)

Simplistic Attachment and Multispectral Imaging with Semiconductor Nanocrystals
by: Sara G. Becker-Catania, et al.
Published: (2011-11-01)

Stratification by Tumor Grade Groups in a Holistic Evaluation of Machine Learning for Brain Tumor Segmentation
by: Snehal Prabhudesai, et al.
Published: (2021-10-01)

Editorial: Multiplexed image analysis for translational research project applications
by: Vera Luiza Capelozzi, et al.
Published: (2022-11-01)

Meningioma presenting as temporal region swelling: Diagnosis by cytopathology and immunohistochemical confirmation on cell block preparation
by: Anila Kunjulekshmi Amma Raveendran Nair, et al.
Published: (2015-01-01)

Solitary Fibrous Tumor of the Parotid Gland in a Young Female: A Rare Case Report and Review of the Literature
by: Megha Ralli, et al.
Published: (2018-01-01)

Components of the tumor immune microenvironment based on m‐IHC correlate with prognosis and subtype of triple‐negative breast cancer
by: Luyi Lin, et al.
Published: (2023-12-01)

Lowering the computational barrier: Partially Bayesian neural networks for transparency in medical imaging AI
by: Snehal Prabhudesai, et al.
Published: (2023-02-01)

Single-plate Molteno implants in complicated glaucomas : Results, survival rates, and complications
by: Neelakantan Arvind, et al.
Published: (1994-01-01)

Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry
by: Denys Rujchanarong, et al.
Published: (2021-09-01)

Integrative Analysis of mRNA, microRNA, and Protein Correlates of Relative Cerebral Blood Volume Values in GBM Reveals the Role for Modulators of Angiogenesis and Tumor Proliferation
by: Arvind Rao, et al.
Published: (2016-01-01)

Integrative Analysis of mRNA, microRNA, and Protein Correlates of Relative Cerebral Blood Volume Values in GBM Reveals the Role for Modulators of Angiogenesis and Tumor Proliferation
by: Arvind Rao, et al.
Published: (2016-03-01)

Composting of grease trap scum waste and green waste: Studying the effects of mix composition on physicochemical and biological process parameters
by: Santhoshi Chitthaluri, et al.
Published: (2023-07-01)

Immunophenotyping of chronic B-cell neoplasms: flow cytometry versus immunohistochemistry
by: Afaf Abdel-Aziz Abdel-Ghafar, et al.
Published: (2012-02-01)

Fascin overexpression is associated with higher grades of breast cancer
by: Ata Abbasi, et al.
Published: (2020-03-01)

Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer
by: Marie Christine Wulff Westergaard, et al.
Published: (2020-12-01)

Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction
by: Joseph J. Sepe, PhD, et al.
Published: (2022-09-01)

Molecular and pathogenetic aspects of tumor budding in colorectal cancer
by: Heather eDawson, et al.
Published: (2015-03-01)

The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation
by: Matthew P. Humphries, et al.
Published: (2020-06-01)

Adenoma of nonpigmented epithelium of the ciliary body presenting as anterior uveitis and glaucoma: A case report
by: Biswas Jyotirmay, et al.
Published: (1995-01-01)

A case of Endometrioid endometrial adenocarcinoma with synchronous low-grade Appendiceal mucinous neoplasm and Pseudomyxoma peritonei
by: Shweta Raje, et al.
Published: (2021-01-01)

A Bayesian 2D functional linear model for gray-level co-occurrence matrices in texture analysis of lower grade gliomas
by: Thierry Chekouo, et al.
Published: (2020-01-01)

Epithelioid hemangioma of penis mimicking malignancy: A rare case
by: Manjari Kishore, et al.
Published: (2017-01-01)

Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer
by: Michal M Hoppe, et al.
Published: (2021-05-01)

Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience
by: Mee-seon Kim, et al.
Published: (2020-05-01)

Immunohistochemistry (IHC) staining of in-vitro cancer cell-generated tumoroids
by: Meitham Amereh, et al.
Published: (2023-01-01)

HER 2 Expression in Gastric and Gastro-esophageal Junction (GEJ) Adenocarcinomas
by: Indu Rajagopal, et al.
Published: (2015-03-01)

Detección inmunohistoquímica del receptor del factor de crecimiento epidérmico: revisión de algunos aspectos técnicos relacionados
by: Rancés Blanco Santana, et al.

A Study of Epidermal Growth Factor Receptor 2 (HER2/neu) Expression in Endoscopic Biopsies and Gastrectomy Specimens of Gastric Adenocarcinomas
by: Sheela Devi CS, et al.
Published: (2016-10-01)

Relationship between MMP-11 Expression in Invasive Ductal Breast Carcinoma with its Clinicopathologic Parameters
by: Farshad Naghshvar, et al.
Published: (2017-04-01)

Genome-wide screening of mRNA expression in leprosy patients.
by: Andrea Faria Fernandes Belone, et al.
Published: (2015-11-01)

Association of graph-based spatial features with overall survival status of glioblastoma patients
by: Joonsang Lee, et al.
Published: (2023-10-01)

Spatial Habitat Features Derived from Multiparametric Magnetic Resonance Imaging Data Are Associated with Molecular Subtype and 12-Month Survival Status in Glioblastoma Multiforme.
by: Joonsang Lee, et al.
Published: (2015-01-01)