Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure

Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure

Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde‐treated bioprosthetic heart valves (BHVs) are well studied, those responsible for the failure of BHVs fixed with alternative next‐generation chemicals remain largely unknown. This study aimed to investigate...

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Bibliographic Details
Main Authors: Alexander E. Kostyunin, Tatiana V. Glushkova, Arseniy A. Lobov, Evgeny A. Ovcharenko, Bozhana R. Zainullina, Leo A. Bogdanov, Daria K. Shishkova, Victoria E. Markova, Maksim A. Asanov, Rinat A. Mukhamadiyarov, Elena A. Velikanova, Tatiana N. Akentyeva, Maria A. Rezvova, Alexander N. Stasev, Alexey V. Evtushenko, Leonid S. Barbarash, Anton G. Kutikhin
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
bacterial invasion
bioprosthetic heart valves
matrix metalloproteinases
neutrophil infiltration
structural valve degeneration
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.028215

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.122.028215

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