Modeling oxidative injury response in human kidney organoids

Modeling oxidative injury response in human kidney organoids

Abstract Background Hemolysis occurs in many injury settings and can trigger disease processes. In the kidney, extracellular hemoglobin can induce damage via several mechanisms. These include oxidative stress, mitochondrial dysfunction, and inflammation, which promote fibrosis and chronic kidney dis...

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Bibliographic Details
Main Authors: Aneta Przepiorski, Thitinee Vanichapol, Eugenel B. Espiritu, Amanda E. Crunk, Emily Parasky, Michael D. McDaniels, Dave R. Emlet, Ryan Salisbury, Cassandra L. Happ, Lawrence A. Vernetti, Matthew L. MacDonald, John A. Kellum, Thomas R. Kleyman, Catherine J. Baty, Alan J. Davidson, Neil A. Hukriede
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Stem Cell Research & Therapy
Subjects:
Kidney organoids
iPSCs
Renal injury
ROS
Hemin
Mitochondria
Online Access:https://doi.org/10.1186/s13287-022-02752-z

Internet

https://doi.org/10.1186/s13287-022-02752-z

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